Endocrine Abstracts

Adrenal masses are among the most prevalent human tumors and are frequently detected unexpectedly by imaging studies performed for reasons unrelated to suspect of adrenal diseases.Subclinical hypercortisolism (SH) is the most frequent endocrine dysfunction detected in patients with adrenal incidentalomas (AI), accounting from five to 20% of all cases depending on inclusion criteria. one mg overnight dexamethasone suppression test (one mg DST) should be t...

Primary amenorrhea is a rare disease that affects <1% of adolescent girls. The most common causes of primary amenorrhea include chromosomal abnormalities, hypothalamic and pituitary disorders, lack or structural abnormality of reproductive organs.18 years old woman was referred to us by her pediatric physician for evaluation of primary amenorrhea and hirsutism. She had low birth weight, 1.9 kg, and hypostaturism. At the age of 6 years underwent to cl...

Background: Actually mitotane is an adrenal-specific agent employed in the treatment of adrenocortical carcinoma (ACC), and although it has been used for several decades, its exact mechanism of action, remain to be fully elucidated. Some authors reported that mitotane affected in vitro the multidrug resistance gene mdr-1/P-glycoprotein. MRP1, belonging a multidrug resistance protein family, exerts a chemo-resistance activity in many type of cancer leading to the failure...